I've used both advantage and frontline and out of the two frontline always was more effective than advantage on my cats and my dogs.My vet George Steedly recommends it to all of his patients and it is easier to measure out in a syringe.

Pros: better on ticks than advantage

Cons: don't work as long as it is suppose to

This product was great for one of my cats the other had an allergic reaction but it still worked great for flea control

Pros: works great for fleas

Cons: some cats are allergic

This product is great for outdoor cats and other cats exposed to fleas and ticks. But if you have a bad flea problem and no ticks with an indoor cat, this would not be my product of choice. I would use advantage in that case. But most cats need protection from fleas and ticks, so this is the product of choice.

Pros: Works great

Cons: none

Frontline isn't the most effective defense against fleas/ticks anylonger, but finding a product that is effective and safe for CATS is more challenging than for dogs. I use Comfortis on my dogs since ticks aren't a problem, but I use Frontline on my cats since they are indoor/outdoor and living near the woods, they are prone to bringing ticks with them when they return home. I occasionally slack on flea control for my dogs, but with roaming cats in the woods, it's a MUST. I'm an ex-vet tech, and thru all my experiences with flea/tick prevention and cats, frontline seems to be the most effective product I've found. My cats hate having it put on, they very much dislike the drops on their backs, but they get over it quickly. Pretty easy to use (assuming you have a mild/good temepered cat!) and the cost is very comprable to similar products but Frontline can boast a higher efficiency. As I said, it's lost some of it's power over the years due to increased resistance from fleas, but it seems to be pretty effective as far as ticks go.

Pros: No irritation, semi-effective

Cons: greasy, cats hate it

Although we don't see as many problems with tick diseases in cats, I do like this product to kill as many ticks as possible as well as protect against fleas. (There are some tick-borne diseases that can be a problem for cats, so I like to use a product that isn't just flea only.)

Pros: gets fleas and ticks

Cons: none